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MDS Panel by FISH
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MDS Panel by FISH

Test name:
MDS panel by FISH (-5, del5q, -7 del7q, trisomy 8, deletion 20q12)

Order name:
MDS panel by FISH request

Specimen requirements:
Sodium heparin peripheral blood or bone marrow

Minimum volume:
1 mL

Storage and stability information:
Room temperature 3 days

Test performed:
Twice per week

Methodology:
Fluorescence in situ hybridization (FISH)

Reference range:
See lab report

Clinical significance:
Chromosome abnormalities are found at diagnosis in about 60% of patients with de novo myelodysplastic syndrome (MDS) and almost 85% of those with secondary MDS. Abnormalities involving chromosome 5 or 7 are poor prognostic findings.  Trisomy 8 has an intermediate prognosis dependent on other cytogenetic abnormalities. Deletion of the long arm of chromosome 20, as the sole cytogenetic abnormality, confers a favorable prognosis.

CPT codes:
88368 x 6


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