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EGFR Mutation
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EGFR Mutation

Test name:
EGFR mutation

Order name:
EGFR

Specimen requirements:
Formalin-fixed paraffin embedded tissue (FFPE)

Minimum volume:
5-10 10µm sections of FFPE tissue in a sterile cup with stained H&E of same block.
If tumor percentage is less than 10% of total nuclei, macrodissection is required, send 5-10 10µm thickness unstained slides with stained H&E of same block.

Storage and stability information:
Room temperature

Test performed:
Once per week

Methodology:
Real-time Polymerase Chain Reaction (PCR)

Reference range:
No EGFR mutation detected

Clinical significance:
Somatic mutations in the epidermal growth factor receptor (EGFR) gene have been associated with non-small cell lung cancer (NSCLC) patients’ responsiveness to tyrosine kinase inhibitors (TKI) (gefinitib, erlotinib). However, while some mutations have a sensitizing effect, other mutations are linked to TKI resistance.

CPT codes:
81401


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