Formalin-fixed paraffin embedded tissue (FFPE)
5-10 10µm sections of FFPE tissue in a sterile cup with stained H&E of same block.
If tumor percentage is less than 10% of total nuclei, macrodissection is required, send 5-10 10µm thickness unstained slides with stained H&E of same block.
Storage and stability information:
Once per week
Real-time Polymerase Chain Reaction (PCR)
No KRAS mutation detected
Mutations in the K-RAS oncogene are frequently found in human cancers. The presence of these mutations has been shown to correlate with a lack of response to certain EGFR inhibitor therapies, such as cetuximab and panitumumab, in metastatic colorectal cancer patients. Screening for the K-RAS mutations aids doctors in selecting appropriate therapies for patients.