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BRAF V600E Mutation
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BRAF V600E Mutation

Test name:
BRAF V600E mutation

Order name:
BRAF

Specimen requirements:
Formalin-fixed paraffin embedded tissue (FFPE)

Minimum volume:
5-10 10µm sections of FFPE tissue in a sterile cup with stained H&E of same block.
If tumor percentage is less than 10% of total nuclei, macrodissection is required, send 5-10 10µm thickness unstained slides with stained H&E of same block.

Storage and stability information:
Room temperature

Test performed:
Once per week

Methodology:
Real-time Polymerase Chain Reaction (PCR)

Reference range:
No BRAF V600E mutation detected

Clinical significance:
BRAF is found in approximately 15% of colon tumors that do not contain a KRAS mutation. Patients whose colon cancer is positive for the BRAF mutation have poor response to anti-EGFR therapy and a worse prognosis based on time to progression and survival data, especially when the cancer is microsatellite stable.
Detection of the BRAF mutation is also useful in aiding the diagnosis of papillary thyroid carcinoma or anaplastic thyroid carcinoma, and in the identification of melanoma tumors that may respond to BRAF-targeted therapies

CPT codes:
81210


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