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Test name:

Order name:
MLL by FISH request

Specimen requirements:
Sodium heparin peripheral blood or bone marrow

Minimum volume:
1 mL

Storage and stability information:
Room temperature 3 days

Test performed:
Twice per week

Fluorescence in situ hybridization

Reference range:
See lab report

Clinical significance:
Abnormalities of 11q23 involving the MLL gene are found in 7% of cytogenetically abnormal acute myelogenous leukemia (AML) cases and approximately 1/3 of those cases are treatment-related due to prior chemotherapy with epipodophyllotoxins and doxorubicin.  MLL is known to have multiple different translocation partners and most cases respond poorly to treatment and have a poor prognosis.  Cytogenetic analysis is required to identify specific MLL translocation partners.  MLL rearrangements can also be identified in a subtype of B-acute lymphoblastic leukemias, particularly in neonates, and also in a subtype of mixed phenotype acute leukemias.  

CPT codes:
88368 x 2

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