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Mental Decline Seen Earlier When Epilepsy Present, Study Suggests

Seizures may hasten Alzheimer's and mild memory problems, researchers say

FRIDAY, July 12 (HealthDay News) -- People with epilepsy appear to show signs of mild memory problems or Alzheimer's disease earlier than those without epilepsy, according to a new study.

"Careful identification and treatment of epilepsy in such patients may improve their clinical course," concluded Dr. Keith Vossel, of the Gladstone Institute of Neurological Disease in San Francisco, and colleagues.

The researchers evaluated data on 54 patients and found that those with mild memory problems and epilepsy showed signs of mental decline nearly seven years earlier than those with mild memory problems who did not have epilepsy -- average age 64 years versus 71 years.

In addition, Alzheimer's patients with epilepsy showed signs of mental decline about five years earlier than those with Alzheimer's who did not have epilepsy -- average age about 65 years versus 70 years, according to the findings published online July 8 in the journal JAMA Neurology.

Alzheimer's increases a patient's risk of seizures, and patients with Alzheimer's and seizure disorders have greater mental impairment, more rapid progression of symptoms and show more severe loss of neurons at autopsy than those without seizures, the researchers noted in a journal news release.

"Epileptic activity associated with Alzheimer's disease deserves increased attention because it has a harmful impact on these patients, can easily go unrecognized and untreated, and may reflect pathogenic processes that also contribute to other aspects of the illness," the study authors wrote.

More information

The U.S. National Institute on Aging has more about Alzheimer's disease.


SOURCE: JAMA Neurology, news release, July 8, 2013

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