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PML-RARA t(15/17) by FISH
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PML/RARA t(15;17) by FISH

Test name:
t(15;17) by FISH (or PML/RARA)

Order name:
t(15;17) by FISH request

Specimen requirements:
Sodium heparin peripheral blood or bone marrow

Minimum volume:
1 mL

Storage and stability information:
Room temperature 3 days

Test performed:
Twice per week

Methodology:
Fluorescence in situ hybridization

Reference range:
See lab report

Clinical significance:
The t(15;17) translocation has been described in almost 100% of APL cases, has the highest complete remission rate, and the longest median survivals for patients with AML.  Most cases are de novo, but approximately 5% occur after previous chemotherapy, mainly drugs targeting topoisomerase II.  Although the outcome of APL is favorable, the high tendency for disseminated intravascular coagulation (DIC) is a serious threat.

CPT codes:
88368 x 2


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