Myeloma Panel by FISH

Test name:
Myeloma panel by FISH (CEP 5/9/15, del13q14, IGH, t(11;14), TP53) 

Order name:
Myeloma panel by FISH request

Specimen requirements:
Sodium heparin peripheral blood or bone marrow

Minimum volume:
1 mL

Storage and stability information:
Room temperature 3 days

Test performed:
Twice per week

Methodology:
Fluorescence in situ hybridization

Reference range:
See lab report

Clinical significance:
Chromosomal abnormalities are found in 30-50% of patients with multiple myeloma. The abnormality detection rate is greatly increased by FISH analysis.  Using FISH, aneuploidy is detected in 67-90% of cases, while rearrangements of IGH translocations are found in at least 65-70% of patients with the t(11;14) translocation representing 10%.  Deletions of 13q or loss of chromosome 13 are found by FISH in 20-30% of patients.  These abnormalities are associated with a significant lower rate of response to conventional chemotherapy and to a shorter survival.  Deletions of TP53 are also known to have a poor prognosis.

CPT codes:
88368 x 11