MYC/IGH t(8;14) by FISH
FISH, MYC/IGH t(8;14)
t(8;14) by FISH request
Sodium heparin peripheral blood or bone marrow. Formalin fixed paraffin-embedded tissue (FFPE)
1mL blood or bone marrow. FFPE – 2 unstained 4µm thick sections on positively charged slides plus 1 stained H&E slide of the same block
Storage and stability information:
Room temperature 3 days for blood and bone marrow. FFPE at room temperature indefinitely.
Twice per week
Fluorescence in situ hybridization
See lab report
The t(8;14) translocation leads to juxtaposition of the Immunoglobulin Heavy Chain loci with the MYC gene. The t(8;14) is associated with B-cell neoplasms, particularly Burkitt lymphoma/leukemia, although it is not specific for this neoplasm. In addition, as the MYC gene can rearrange with other loci, the absence of the t(8;14) does not exclude the diagnosis of Burkitt lymphoma.
88368 x 2