MYC Breakapart by FISH

Test name:
FISH, MYC breakapart by FISH

Order name:
MYC breakapart by FISH request

Specimen requirements:
Sodium heparin peripheral blood or bone marrow. Formalin fixed paraffin-embedded tissue (FFPE)

Minimum volume:
1mL blood or bone marrow. FFPE – 2 unstained 4µm thick sections on positively charged slides plus 1 stained H&E slide of the same block

Storage and stability information:
Room temperature 3 days for blood and bone marrow. FFPE at room temperature indefinitely.

Test performed:
Twice per week

Methodology:
Fluorescence in situ hybridization

Reference range:
See lab report

Clinical significance:
Rearrangements of MYC are associated with B-cell neoplasms and are found in both Burkitt lymphoma/leukemia and B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma.  Translocation of the MYC 8q24 region may be to the Immunoglobulin heavy chain locus (14q32), either the kappa or lambda immunoglobulin light chain loci (2p12 and 22q11, respectively) as well as to non-immunoglobulin loci.

CPT codes:
88368 x 3