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KRAS Mutation
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KRAS Mutation

Test name:
KRAS mutation

Order name:
KRAS

Specimen requirements:
Formalin-fixed paraffin embedded tissue (FFPE)

Minimum volume:
5-10 10µm sections of FFPE tissue in a sterile cup with stained H&E of same block.
If tumor percentage is less than 10% of total nuclei, macrodissection is required, send 5-10 10µm thickness unstained slides with stained H&E of same block.

Storage and stability information:
Room temperature

Test performed:
Once per week

Methodology:
Real-time Polymerase Chain Reaction (PCR)

Reference range:
No KRAS mutation detected

Clinical significance:
Mutations in the K-RAS oncogene are frequently found in human cancers. The presence of these mutations has been shown to correlate with a lack of response to certain EGFR inhibitor therapies, such as cetuximab and panitumumab, in metastatic colorectal cancer patients. Screening for the K-RAS mutations aids doctors in selecting appropriate therapies for patients.

CPT codes:
81275


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