CLL Panel by FISH

Test name:
CLL panel by FISH (del(13)(q14.3), trisomy12, del(11)(q22.3), del(17)(p13.1))

Order name:
CLL panel by FISH request

Specimen requirements:
Sodium heparin peripheral blood or bone marrow

Minimum volume:
1 mL

Storage and Stability information:
Room temperature 3 days

Test performed:
Twice per week

Methodology:
Fluorescence in situ hybridization

Reference range:
See lab report

Clinical significance:
Chromosome abnormalities are found in about 50% of cases by chromosome analysis and in about 80% of chronic lymphocytic leukemia (CLL) cases by fluorescence in situ hybridization (FISH) of interphase cells.  The most frequent changes are deletion 13q (55%), deletion 11q (18%), trisomy 12 (16 %), and deletion 17p (7%).

CPT codes:
88368 x 5