CCND1/IGH t(11;14) by FISH
FISH, CCND1/IGH t(11;14)
t(11;14) by FISH request
Sodium heparin peripheral blood or bone marrow. Formalin fixed paraffin-embedded tissue (FFPE)
1mL blood or bone marrow. FFPE – 2 unstained 4µm thick sections on positively charged slides plus 1 stained H&E slide of the same block
Storage and stability information:
Room temperature 3 days for blood and bone marrow. FFPE at room temperature indefinitely.
Twice per week
Fluorescence in situ hybridization
See lab report
The t(11;14) translocation leads to juxtaposition of the Immunoglobulin Heavy Chain loci with the CCND1 (Cyclin D1) gene and is found in almost all cases of mantle cell lymphoma. The t(11;14) is not specific for mantle cell lymphoma however, as it can be identified in other B-cell neoplasms, including plasma cell myeloma.
88368 x 2