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Test name:
BCR/ABL1, t(9;22) by FISH

Order name:
BCR/ABL1 by FISH request

Specimen requirements:
Sodium heparin peripheral blood or bone marrow

Minimum volume:
1 mL

Storage and stability information:
Room temperature 3 days

Test performed:
Twice per week

Fluorescence in situ hybridization

Reference range:
See lab report

Clinical significance:
The abnormality, t(9;22)(q34;q11.2) has been identified in 90% of cases of chronic myeloid leukemia (CML).  The remaining cases of CML have other variant translocations that create the BCR/ABL1 fusion and that can also be detected by this assay.  The t(9;22)(q34;q11.2) translocation can also be detected in 20% of adult cases and 3% of pediatric cases of B acute lymphoblastic leukemia (B-ALL).  The t(9;22)(q34;q11.2) translocation can also be present in mixed phenotype acute leukemia (MPAL), which accounts for <1% of acute leukemias.  

CPT codes:
88368 x 2


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