B-cell Gene Rearrangement
B-cell receptor gene rearrangement, PCR, cell-based
B-CELL GENE RR
EDTA peripheral blood and bone marrow, fresh tissue in RPMI, Formalin-fixed paraffin embedded tissue (FFPE)
0.5 mL peripheral blood or bone marrow
FFPE: 5-10 10µm thickness curls submitted in a sterile cup along with stained H & E of same block) If tumor percentage is less than 10% of total nuclei, macrodissection is required, send 5-10 10µm thickness unstained slides with stained H&E of same block.
Storage and stability information:
Blood and bone marrow (Room temperature, 1 week), fresh tissue (refrigerated, 1 week), FFPE (room temperature)
Once per week
Polymerase Chain Reaction (PCR), Capillary Electrophoresis
No clonal population detected
This test is used to aid in the diagnosis of B-cell malignancies, to determine lineage of leukemias and lymphomas for prognosis and treatment selection, and to detect minimal residual disease or recurrent disease.