AML Panel by FISH

Test name:
AML panel by FISH (inv16, t(15;17), t(8;21), MLL)

Order name:
AML panel by FISH request

Specimen requirements:
Sodium heparin peripheral blood or bone marrow

Minimum volume:
1 mL

Storage and stability information:
Room temperature 3 days

Test performed:
Twice per week

Methodology:
Fluorescence in situ hybridization

Reference range:
See lab report

Clinical significance:
The t(8;21) translocation is found in 7-8% of patients with cytogenetically abnormal acute myelogenous leukemia (AML) and in adults usually predicts good response to chemotherapy with a high remission rate and a relatively long median survival. Abnormalities of 11q23 are found in 2% of cytogenetically abnormal adult AML cases and 10% of pediatric AML cases and are generally associated with a poor prognosis.  The t(15;17) translocation has been described in almost 100% of Acute Promyelocytic Leukemia (APL) cases. This subtype of AML is sensitive to all-trans retinoic acid (ATRA) has the highest complete remission rate, and the longest median survivals for patients with AML.  Inversion of chromosome 16 is seen in 4% of cytogenetically abnormal AML cases and has a very high complete remission rate and long median survival.

CPT codes:
88368 x 8